6-Bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-one
| Makhalidwe a mankhwala | 6-Bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-one ndi madzi owonekera bwino opanda mtundu kapena wachikasu wopepuka, osasungunuka m'madzi, osungunuka mu CHCl3, malo osungiramo ayenera kusungidwa mufiriji, kulekanitsidwa ndi zinthu zowononga ma oxidants, mankhwala odyedwa, kutali ndi moto, komanso gwero la kutentha. | |
| Mapulogalamu | 6-Bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-onendi mankhwala apakati a Alectinib, mankhwala oletsa lymphoma kinase (ALK) omwe amasankha bwino komanso amphamvu kwambiri omwe amatha kuletsa gatekeeper mutant yolimba, zomwe zimapangitsa kuti maselo asamakule bwino. | |
| Mawonekedwe enieni | Madzi opanda mtundu mpaka achikasu | |
| Nthawi yosungira zinthu | Malinga ndi zomwe takumana nazo, mankhwalawa akhoza kusungidwa kwa masiku 12.miyezi kuyambira tsiku loperekedwa ngati zasungidwa m'zidebe zotsekedwa bwino, zotetezedwa ku kuwala ndi kutentha ndikusungidwa kutentha pakati pa 5 -30°C. | |
| Tkatundu wamba
| Malo Owira | 354.7±42.0 °C pa 760 mmHg |
| Pophulikira | 168.3±27.9 °C | |
| Misa Yeniyeni | 282.025543 | |
| PSA | 26.30000 | |
| LogP | 3.25 | |
| Kupanikizika kwa nthunzi | 0.0±0.8 mmHg pa 25°C | |
| Mndandanda wa Kusinthasintha | 1.545 | |
| pka | 1.26±0.10(Yanenedweratu) | |
| Kusungunuka kwa Madzi | 50 mg/ml mu CHCl3 | |
Chitetezo
Mukamagwiritsa ntchito mankhwalawa, chonde tsatirani malangizo ndi chidziwitso chomwe chaperekedwa mu pepala la deta yachitetezo ndipo tsatirani njira zodzitetezera komanso zaukhondo kuntchito zoyenera pogwiritsira ntchito mankhwala.
Zindikirani
Deta yomwe ili m'buku lino imachokera ku chidziwitso chathu chamakono komanso zomwe takumana nazo. Poganizira zinthu zambiri zomwe zingakhudze kukonza ndi kugwiritsa ntchito malonda athu, deta iyi siimasula opanga kuti achite kafukufuku wawo ndi kuyesa; deta iyi sikutanthauza chitsimikizo chilichonse cha katundu wina, kapena kuyenerera kwa malondawo pacholinga china. Mafotokozedwe aliwonse, zojambula, zithunzi, deta, kuchuluka, kulemera, ndi zina zotero zomwe zaperekedwa pano zitha kusintha popanda chidziwitso cham'mbuyomu ndipo sizipanga mtundu wa malonda womwe wavomerezedwa. Ubwino wa malonda womwe wavomerezedwa umachokera kokha ku mawu omwe aperekedwa mu ndondomeko ya malonda. Ndi udindo wa wolandira malonda athu kuonetsetsa kuti ufulu uliwonse wa mwiniwake ndi malamulo ndi malamulo omwe alipo akutsatiridwa.
